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superporous ipn hydrogels having enhanced

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(PDF) Superporous polyacrylate/chitosan IPN hydrogels for

The hydrogels have a structure of interconnected pores with pore sizes of approximately 100-150 m. Qiu Y, Park K. Superporous IPN hydrogels having enhanced. mechanical properties. AAPS Pharm Advances in porous chitosan-based composite hydrogels Jan 01, 2020 · An increase in the cross-linker ratio from 1/80 to 1/20 led to a more stable porous morphology for PAAm/CS hydrogels with pores sizes of about 4550 m [].In another study, new porous GEL/CS/Ag composites (Fig. 2B) have been obtained by freeze-drying of swollen gels prepared by blending GEL/Ag with CS and cross-linked with tannic acid.The SEM micrographs indicated that

Beneficial properties for insulin absorption using

Feb 28, 2008 · As shown in Fig. 1, insulin release from SPH-IPN 144 exhibited sensitivity towards pH. When pH increased from 1.0 to 6.2, the release rate increased and more insulin was released at the end of the experiment (2 h). At pH 6.2 and 7.4, the release behavior appeared similar in that more than 80% of the insulin was released within 30 min and the remaining insulin was almost released up within 2 h. Comparison of various generations of superporous hydrogels Jul 29, 2013 · Further superporous hydrogel composites (SPHCs) (as discussed by Park et al. [710]) or by the formation of interpenetrating (as discussed by Qiu and Park ) or hybrid hydrogel network (as discussed by Omidian et al. ) have been developed with enhanced mechanical strength. Interpenetrating polymer networks (IPN) are a mixture of two or more Kinam Park's research works Purdue University, IN Superporous IPN hydrogels having enhanced mechanical properties. Article. Nov 2003; Yong Qiu. Kinam Park. The objective of this study was to improve the mechanical properties of superporous

Preparation of Gastro-retentive Tablets Employing

Nov 12, 2020 · Qiu Y, Park K. Superporous IPN hydrogels having enhanced mechanical properties. AAPS PharmSciTech. 2003;4(4):40612. CAS Article Google Scholar 20. Gupta NV, Shivakumar H. Preparation and characterization of superporous hydrogels as gastroretentive drug delivery system for rosiglitazone maleate. DARU J Pharm Sci. 2010;18(3):200. SUPER POROUS HYDROGEL:A PROMISING Superporous hydrogels (SPHs) were originally developed as a novel drug delivery system for those drugs having absorption window in stomach and upper part of the gastrointestinal tract. Superporous hybrid hydrogels based on polyacrylamide Conventional SPH have the major disadvantage of their weak mechanical strength.[4,5] Further, improvement in mechanical properties is deemed necessary in case of SPH, which can be achieved by synthesis of superporous hydrogel composites (SPHCs)[6,7,8,9] or interpenetrating/hybrid hydrogel

Superporous hydrogels containing poly(acrylic acid-co

Feb 01, 2007 · An enhanced loading capacity for insulin could be obtained by the SPH-IPNs as compared to non-porous hydrogel and CSPH, and more than 90% of the insulin was released within 1 h. With the improved mechanical properties, in vitro muco-adhesive force and loading capacities, the SPH-IPN may be used as a potential muco-adhesive system for peroral Superporous hydrogels containing poly(acrylic acid-co Feb 01, 2007 · In the current investigation, superporous hydrogels containing poly (acrylic acid- co -acrylamide)/carboxymethyl chitosan interpenetrating polymer networks (SPH-IPNs) were synthesized to enhance the mechanical strength, in vitro muco-adhesive force and loading capacity of SPHs. Acrylic acid (AA) and acrylamide (AM) were chosen as the base monomers for their high water affinity and fast co Superporous hydrogels containing poly(acrylic acid-co Feb 01, 2007 · In the current investigation, superporous hydrogels containing poly (acrylic acid- co -acrylamide)/carboxymethyl chitosan interpenetrating polymer networks (SPH-IPNs) were synthesized to enhance the mechanical strength, in vitro muco-adhesive force and loading capacity of SPHs. Acrylic acid (AA) and acrylamide (AM) were chosen as the base monomers for their high water affinity and fast co

Superporous polyacrylate/chitosan IPN hydrogels for

In addition, ionically crosslinked chitosan (CH) superporous hydrogels were synthesized to form interpenetrating superporous hydrogels, i.e. poly(AAm)-CH and poly(AAm-co-AA)-CH SPH-IPNs. The hydrogels have a structure of interconnected pores with pore sizes of approximately 100150 m. Superporous polyacrylate/chitosan IPN hydrogels for In addition, ionically crosslinked chitosan (CH) superporous hydrogels were synthesized to form interpenetrating superporous hydrogels, i.e. poly(AAm)-CH and poly(AAm-co-AA)-CH SPH-IPNs. The hydrogels have a structure of interconnected pores with pore sizes of approximately 100150 m. Swelling, strength, and biocompatibility of acrylate-based A new method was adopted to evaluate the swelling capacity and rate in superporous hydrogel hybrid using a modified texture analyzer. Based on the extensive data acquisition, swelling data at any time point were obtainable and fit into a Voigt viscoelastic model. SC. Hydrogels having enhanced elasticity and mechanical strength properties

Synthesis, characterization, mechanical properties and

The swelling ratio of IPNSPH Alg was lower than that of the superporous hydrogel (SPH) and it decreased as the sodium alginate/monomer ratio increased. The IPNSPH Alg exhibited pH responsiveness and saltsensitive properties. Compared to SPH and SPH composites, the mechanical strength of IPNSPH Alg was significantly Yong Qiu - Google ScholarSuperporous IPN hydrogels having enhanced mechanical properties. Y Qiu, K Park. Aaps Pharmscitech 4 (4), 406-412, 2003. 87:2003:Adsorption of Small Drug Particles at Surface of Large Excipients. H Wen, Y Qiu. Pharmaceutical Technology Europe, 2006. 4: Superporous IPN Hydrogels Having Enhanced porous IPN hydrogels (SPIHs) with the improved me-chanical properties are expected to withstand compres-sion pressure and mechanical frictions in the stomach better than the control SPHs. KEYWORDS:superporous hydrogels, interpenetrating polymer networks, polyacrylonitrile, gastric retention devices, elasticity

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